![]() Matzaraki V, Kumar V, Wijmenga C, Zhernakova A. Defining the role of the MHC in autoimmunity: a review and pooled analysis. J Clin Invest 2001 107: 795–796.įernando MMA, Stevens CR, Walsh EC, De Jager PL, Goyette P, Plenge RM et al. DR, DQ, and you: MHC alleles and autoimmunity. HLA-DRB1 the notorious gene in the mosaic of autoimmunity. Cold Spring Harb Symp Quant Biol 1989 54 (Part 1): 1–13.Īrango M-T, Perricone C, Kivity S, Cipriano E, Ceccarelli F, Valesini G et al. Approaching the asymptote? Evolution and revolution in immunology. Peptide cross-reactivity: theoriginal sin of vaccines. No human protein is exempt from bacterial motifs, not even one. Trost B, Lucchese G, Stufano A, Bickis M, Kusalik A, Kanduc D. Quantifying the possible cross-reactivity risk of an HPV16 vaccine. Molecular mimicry: antigen sharing by parasite and host and its consequences. ![]() Molecular mimicry in systemic lupus erythematosus. Self Nonself 2010 1: 255–258.Īgmon-Levin N, Blank M, Paz Z, Shoenfeld Y. Massive peptide sharing between viral and human proteomes. Kanduc D, Stufano A, Lucchese G, Kusalik A. Molecular mimicry and immune-mediated diseases. Antigenic cross-reaction between host and parasite as a possible cause of pathogenicity. An immunological cross-reaction between group-a streptococcal cells and human heart tissue. Finally, we refer to possible implications on the potential future development of better, safer vaccines. We further review the principal examples of the influenza, hepatitis B, and human papilloma virus vaccines, all suspected to induce autoimmunity via molecular mimicry. In this review, we address the concept of molecular mimicry and its application in explaining post vaccination autoimmune phenomena. This similarity may lead to immune crossreactivity, wherein the reaction of the immune system towards the pathogenic antigens may harm the similar human proteins, essentially causing autoimmune disease. Molecular mimicry refers to a significant similarity between certain pathogenic elements contained in the vaccine and specific human proteins. Among the implicated mechanisms for these reactions is molecular mimicry. Such adverse reactions to vaccines may be viewed as a result of the interaction between susceptibility of the vaccinated subject and various vaccine components. It is therefore pertinent for the scientific community to seriously address public concern of adverse effects of vaccines to regain public trust in these important medical interventions. However, during the past two decades, there has been growing awareness of possible adverse events associated with vaccinations, cultivating heated debates and leading to significant fluctuations in vaccination rates. ![]() Since the early 1800s vaccines have saved numerous lives by preventing lethal infections. ![]()
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